AUXILIUM is a specialty biopharmaceutical company committed to developing innovations for unmet medical needs like Dupuytren’s disease.
Enroll now to get free patient education tools and information about Dupuytren’s disease.
Enroll now to get free patient education tools and information about Dupuytren’s disease.
|
How is the Dupuytren’s disease process thought to occur? |
Answers |
|
 |
Myofibroblasts align along longitudinal lines of mechanical stress to form a dense fibrous cord |
3 |
 |
Local microvascular ischemia leads to overproliferation of fibroblasts |
1 |
 |
Thickened fascia becomes hypovascular and almost totally collagenous |
5 |
 |
Fibrous nodules form, containing fibroblasts in bundles of collagen |
2 |
 |
Collagen remodeling becomes unbalanced, with increased collagen deposition and reduced collagen degradation |
4 |
Committed to developing a nonsurgical
choice for Dupuytren’s disease
choice for Dupuytren’s disease
References: Benson LS, Williams CS, Kahle M. Dupuytren’s contracture.
J Am Acad Orthop Surg. 1998;6:24-35. Hurst LC, Badalamente MA.
Histopathology and cell biology. In: Tubiana R, Leclercq C, Hurst LC,
Badalamente MA, Mackin EJ, eds. Dupuytren’s Disease. London:
Martin Dunitz Ltd; 2000:59-77.
J Am Acad Orthop Surg. 1998;6:24-35. Hurst LC, Badalamente MA.
Histopathology and cell biology. In: Tubiana R, Leclercq C, Hurst LC,
Badalamente MA, Mackin EJ, eds. Dupuytren’s Disease. London:
Martin Dunitz Ltd; 2000:59-77.
